Everything about arthritis rheumatoid symptoms

The majority of people in the world suffer from an immune system that doesn't distinguish between healthy cells, invader bacteria and disease. Disease defences that once protected them are now attacking their organs and tissue.




A number of major international research efforts are underway to fight this trend - for instance, a London-based initiative called the Francis Crick Institute, where two world experts, James Lee and Carola Vinuesa, have created separate research groups that will help identify the root causes of autoimmune disease, as these conditions are known.


Lee stated that cases of autoimmune disease are on the rise since around 40 years ago in the West. There are new cases in countries where these conditions were not seen before.


The Middle East and East Asia have seen the highest increase in cases of inflammatory bowel diseases. Before this, people had barely had any experience with the disease.


Type 1 diabetes is one of the autoimmune diseases. Other diseases include rheumatoid, inflammation of the bowel, and multiple sclerosis. In all cases the immune system has its wires crossed, and it turns on healthy tissue instead of the infectious agents.


In the UK alone, more than 4 million people have been diagnosed with the condition, with some people suffering more than one. In the world, it's believed that the incidence of autoimmune diseases are growing by 3% to 9% a year. Researchers believe that environmental triggers play a major role in this rise.


Human genetics haven't changed over the last few years, according to Lee, who was previously based at Cambridge University. There must be a change in the outside world in a way that is increasing our susceptibility to autoimmune disease.


Vinuesa who was based at Australia National University backed the notion. She cited the changes in food habits that were happening as more countries adopted western-style diets , and people bought more fast food.


Vinuesa said that some vital elements in fast food diets are missing, including fibre. There is evidence to suggest that changing the microbiome of a person (the collection of microorganisms and microbes we have in our digestive tract) could result in a loss in certain bodily functions.


Changes in our microbiomes cause an autoimmune condition, and over 100 have been identified.


The researchers also emphasized that different vulnerability was a factor in the development of these illnesses. These ailments also include celiac disease as well as lupus, which triggers inflammation and swelling and can cause harm to different organs, including the heart.


"If you don't have particular genetic susceptibility but you don't have to be at risk of developing an auto-immune disease regardless of the amount of Big Macs you consume," said Vinuesa. "We are unable to slow the growth of fast-food chains across the globe. Instead, we're focused on the genetic elements which cause autoimmune illnesses. We're trying to figure out what makes certain individuals more vulnerable than others. This is how we want to address the problem."


With the development of technology, scientists are now in a position to detect tiny differences between individuals' DNA. It is possible to find common genetic patterns in people who suffer from an autoimmune condition.


Lee stated that we didn't have the tools to sequence DNA until recent. However, now we have the capability to sequence DNA on large scales, which has had a profound impact in our lives. Inflammatory bowel disease was only one of the DNA variants we had at the time I started my research. Now, there are over 250.


This is at the core of the work done by Lee and Vinuesa. They seek to determine the different ways that genetic pathways work and uncover the various types of diseases doctors are currently studying. Vinuesa said that there could be many versions of some conditions that cause autoimmune disease, such as Lupus. It is important to understand that this has consequences when trying to find the best treatment.


While there are a myriad of effective new therapies in development however, we're not sure which patients they should be administered to. This is due to the fact that we do not know the exact type of their illness. This is an important goal in autoimmune research. In order to provide the appropriate treatment, we must learn how to classify patients.


Lee said that with the rising incidence of autoimmune diseases across the globe, new treatments and medicines are required more urgently than ever. There are currently no cures for autoimmune diseases that usually manifest in young people , as they're trying to complete their education, find their first job and raise Click here families, Lee said.


This means that more people will need to undergo surgery or regular injections throughout their life. It can be devastating for patients and an enormous burden on healthcare services. Therefore, it is crucial to develop new, effective treatment options.


Rheumatoid arthritis is an auto-immune disease. It is caused by the immune system attacks healthy body tissues. However, it's not yet identified what causes this.


The antibodies your immune system produces to fight bacteria and viruses is essential to fight infections.


If you Read More suffer from Rheumatoid Arthritis, your immune systems mistakenly transmits antibodies to your joints' lining, where they attack the surrounding tissues.


This causes the thin, cell-like layer covering your joints (synovium), to become sore and inflamed this releases chemicals that cause harm around the joint.


bones

cartilage is the connective tissue between bones

Tendons, the tissues that join bone to muscle

Ligaments form the connective tissue that connects bone and cartilage.

If the condition is not treated, it can gradually result in the loss of alignment and form. It could eventually cause the destruction of the joint.


While there are many theories that explain why the immune system targets joints, none of them have been proved.

Possible risk factors

You may be more at the risk of developing rheumatoidarthritis when you perform the following:


The genes. There are indications that arthritis rheumatoid may run in families. But, because genes play a minor part in the course of development, there is little chance that the condition will be transferred to the next generation.

hormones - rheumatoid arthritis is more prevalent among women than men, which could be due to effects of the hormone estrogen, however, this connection hasn't been established.

smoking cigarettes - some research suggests that people who smoke are at a higher risk of developing rheumatoid arthritis.